Below are the top 20 results from the following PubMed search, sorted by “Best Match,” limited to the past 10 years: “Amyotrophic Lateral Sclerosis” AND (“neural regeneration” OR “neuron regeneration” OR “nerve regeneration”)

(Last updated Spring 2023)

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach.

Bordoni M, Scarian E, Rey F, Gagliardi S, Carelli S, Pansarasa O, Cereda C.

Int J Mol Sci. 2020 May 4;21(9):3243. doi: 10.3390/ijms21093243.

PMID: 32375302 Free PMC article. Review.

Neurodegenerative disorders (i.e., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinal cord injury) represent a great problem worldwide and are becoming prevalent because of the increasing average age of the population. …In t …

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and Limitations.

Kolagar TA, Farzaneh M, Nikkar N, Khoshnam SE.

Curr Stem Cell Res Ther. 2020;15(2):102-110. doi: 10.2174/1574888X14666190823142911.

PMID: 31441732 Review.

There is urgent need to investigate therapeutic strategies and novel treatments for neural regeneration in disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) …

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice.

Scaricamazza S, Salvatori I, Amadio S, Nesci V, Torcinaro A, Giacovazzo G, Primiano A, Gloriani M, Candelise N, Pieroni L, Loeffler JP, Renè F, Quessada C, Tefera TW, Wang H, Steyn FJ, Ngo ST, Dobrowolny G, Lepore E, Urbani A, Musarò A, Volonté C, Ferraro E, Coccurello R, Valle C, Ferri A.

Br J Pharmacol. 2022 Apr;179(8):1732-1752. doi: 10.1111/bph.15738. Epub 2022 Jan 13.

PMID: 34783031 Free PMC article.

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles and is currently incurable. …Furthermore, tri …

Neurotrophic and Neuroregenerative Effects of GH/IGF1.

Bianchi VE, Locatelli V, Rizzi L.

Int J Mol Sci. 2017 Nov 17;18(11):2441. doi: 10.3390/ijms18112441.

PMID: 29149058 Free PMC article. Review.

The following keywords have been used: “GH/IGF-1” associated with “neuroregeneration”, “amyotrophic lateral sclerosis“, “Alzheimer disease”, “Parkinson’s disease”, “brain”, and “neuron“. RESULTS: Of the retrieved articles, we found nine articles about …

Stem Cells: Innovative Therapeutic Options for Neurodegenerative Diseases?

Bonaventura G, Munafò A, Bellanca CM, La Cognata V, Iemmolo R, Attaguile GA, Di Mauro R, Di Benedetto G, Cantarella G, Barcellona ML, Cavallaro S, Bernardini R.

Cells. 2021 Aug 5;10(8):1992. doi: 10.3390/cells10081992.

PMID: 34440761 Free PMC article. Review.

Here, we provide an update of the current knowledge about source and administration routes of stem cells, and review light and shadows of cells replacement therapy for the treatment of the three main neurodegenerative disorders (Amyotrophic lateral sclerosis, …

Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and Amyotrophic Lateral Sclerosis.

Goyal S, Seth B, Chaturvedi RK.

Curr Pharm Des. 2022;28(10):806-828. doi: 10.2174/1381612827666211115154450.

PMID: 34781865 Review.

Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) are neurological disorders pathologically characterized by chronic degeneration of dopaminergic neurons and motor neurons, respectively. …To date, stem cells and different polyphenols have bee …

Non-motor involvement in amyotrophic lateral sclerosis: new insight from nerve and vessel analysis in skin biopsy.

Nolano M, Provitera V, Manganelli F, Iodice R, Caporaso G, Stancanelli A, Marinou K, Lanzillo B, Santoro L, Mora G.

Neuropathol Appl Neurobiol. 2017 Feb;43(2):119-132. doi: 10.1111/nan.12332. Epub 2016 Jul 7.

PMID: 27288647

AIMS: To assess cutaneous sensory and autonomic nerves and the vascular bed in amyotrophic lateral sclerosis (ALS). METHODS: We enrolled 41 patients (M = 20, aged 63.5 11.8 years), and 41 age- and gender-matched healthy volunteers (M = 20, aged 63.5 11.8 year …

Progressive Degeneration and Inhibition of Peripheral Nerve Regeneration in the SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis.

Deng B, Lv W, Duan W, Liu Y, Li Z, Ma Y, Zhang G, Song X, Cui C, Qi X, Li Y, Li C.

Cell Physiol Biochem. 2018;46(6):2358-2372. doi: 10.1159/000489627. Epub 2018 May 4.

PMID: 29742495 Free article.

BACKGROUND: Myelination, degeneration and regeneration are implicated in crucial responses to injury in the peripheral nervous system. Considering the progression of amyotrophic lateral sclerosis (ALS), we used the superoxide dismutase 1 (SOD1)-G93A tr …

Local Translation in Nervous System Pathologies.

Gamarra M, de la Cruz A, Blanco-Urrejola M, Baleriola J.

Front Integr Neurosci. 2021 Jun 29;15:689208. doi: 10.3389/fnint.2021.689208. eCollection 2021.

PMID: 34276318 Free PMC article. Review.

Locally synthesized proteins can exert their effects at or close to the site of translation, or they can be delivered to distal compartments like the nucleus and induce transcriptional responses that lead to neurodegeneration, nerve regeneration and other cell-wide …

Modeling Neurodegenerative Disorders in Drosophila melanogaster.

Bolus H, Crocker K, Boekhoff-Falk G, Chtarbanova S.

Int J Mol Sci. 2020 Apr 26;21(9):3055. doi: 10.3390/ijms21093055.

PMID: 32357532 Free PMC article. Review.

In this review, we discuss recent progress in Drosophila modeling Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington’s Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or traumat …

Autophagy and neurodegenerative disorders.

Kesidou E, Lagoudaki R, Touloumi O, Poulatsidou KN, Simeonidou C.

Neural Regen Res. 2013 Aug 25;8(24):2275-83. doi: 10.3969/j.issn.1673-5374.2013.24.007.

PMID: 25206537 Free PMC article. Review.

Spinal motor neuron transplantation to enhance nerve reconstruction strategies: Towards a cell therapy.

Bazarek S, Johnston BR, Sten M, Mandeville R, Eggan K, Wainger BJ, Brown JM.

Exp Neurol. 2022 Jul;353:114054. doi: 10.1016/j.expneurol.2022.114054. Epub 2022 Mar 24.

PMID: 35341748 Review.

Nerve transfers have become a powerful intervention to restore function following devastating paralyzing injuries. …Furthermore, this strategy may be used as a permanent axon replacement following destruction of lower motor neurons and would enable exogenous stimulation …

Microtubule Dynamics Following Central and Peripheral Nervous System Axotomy.

Kulkarni R, Thakur A, Kumar H.

ACS Chem Neurosci. 2022 May 4;13(9):1358-1369. doi: 10.1021/acschemneuro.2c00189. Epub 2022 Apr 22.

PMID: 35451811 Review.

It is evident from various studies that although axonal regeneration depends on both cell-extrinsic and cell-intrinsic factors, any therapy that aims at axonal regeneration ultimately converges onto MTs. Understanding the neuronal MT dynamics will help develop effec …

MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases.

Saraiva C, Esteves M, Bernardino L.

Biochem Pharmacol. 2017 Oct 1;141:118-131. doi: 10.1016/j.bcp.2017.07.008. Epub 2017 Jul 11.

PMID: 28709951 Review.

Therefore, these molecules are able to regulate several biological processes, including neuronal survival, differentiation and regeneration. Additionally, miRNA might act as valuable clinical agents in brain pathological conditions. …In this review, we describe miRNA bio …

Mitophagy links oxidative stress conditions and neurodegenerative diseases.

Shefa U, Jeong NY, Song IO, Chung HJ, Kim D, Jung J, Huh Y.

Neural Regen Res. 2019 May;14(5):749-756. doi: 10.4103/1673-5374.249218.

PMID: 30688256 Free PMC article. Review.

Proper regulation of mitophagy is crucial for maintaining homeostasis; conversely, inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species, including reactive oxygen species and reactive nitrogen species, resulting in various neurodegener …

Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models.

Tallon C, Marshall KL, Kennedy ME, Hyde LA, Farah MH.

Neurotherapeutics. 2020 Jul;17(3):973-988. doi: 10.1007/s13311-020-00852-3.

PMID: 32236823 Free PMC article.

(PLoS One 4:12, 2009), negatively regulates peripheral nerve regeneration. Here, we investigated whether pharmacological inhibition of BACE may enhance peripheral nerve repair following traumatic nerve injury or neurodegenerative disease. …Our data d …

ROCK inhibition improves axonal regeneration in a preclinical model of amyotrophic lateral sclerosis.

Joshi AR, Muke I, Bobylev I, Lehmann HC.

J Comp Neurol. 2019 Oct 1;527(14):2334-2340. doi: 10.1002/cne.24679. Epub 2019 Mar 30.

PMID: 30861116

Regeneration of axons was examined after sciatic nerve crush in pre- and symptomatic SOD1(G93A) mice. …Given the lack of treatments for ALS, approaches to improve axonal regeneration, including by inhibiting ROCK, should be further explored….

Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases.

Qu Y, Liu Y, Noor AF, Tran J, Li R.

Neural Regen Res. 2019 Jun;14(6):931-938. doi: 10.4103/1673-5374.250570.

PMID: 30761996 Free PMC article. Review.

Macrophage roles in peripheral nervous system injury and pathology: Allies in neuromuscular junction recovery.

Rios R, Jablonka-Shariff A, Broberg C, Snyder-Warwick AK.

Mol Cell Neurosci. 2021 Mar;111:103590. doi: 10.1016/j.mcn.2021.103590. Epub 2021 Jan 8.

PMID: 33422671 Free PMC article. Review.

At early time points, macrophages perform inflammatory functions, but at later time points, they adopt pro-regenerative phenotypes to support nerve regeneration. Research has largely been limited, however, to the injury site. …Macrophages are present at the NMJ fo …

Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis?

Lennon MJ, Jones SP, Lovelace MD, Guillemin GJ, Brew BJ.

Neurotox Res. 2016 Feb;29(2):201-7. doi: 10.1007/s12640-015-9573-5. Epub 2015 Nov 12.

PMID: 26563995 Review.

Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal, neurodegenerative disease of the human motor system. …