Below are the top 20 results from the following PubMed search, sorted by “Best Match,” limited to the past 10 years: “spinal cord injury” AND (“neural regeneration” OR “neuron regeneration” OR “nerve regeneration”[Title/Abstract:~0])

(Last updated Spring 2023)

SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling.

Liu H, Zhang J, Xu X, Lu S, Yang D, Xie C, Jia M, Zhang W, Jin L, Wang X, Shen X, Li F, Wang W, Bao X, Li S, Zhu M, Wang W, Wang Y, Huang Z, Teng H.

Theranostics. 2021 Feb 20;11(9):4187-4206. doi: 10.7150/thno.49054. eCollection 2021.

PMID: 33754056 Free PMC article.

Axonal degeneration is a common pathological feature in many acute and chronic neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif-containing 1), the fifth TLR (Toll-like receptor) adaptor, has diverse functions in the i …

A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury.

Shen H, Xu B, Yang C, Xue W, You Z, Wu X, Ma D, Shao D, Leong K, Dai J.

Biomaterials. 2022 Jan;280:121279. doi: 10.1016/j.biomaterials.2021.121279. Epub 2021 Nov 25.

PMID: 34847433

Spinal cord injury (SCI) creates an inflammatory microenvironment characterized by damage-associated molecular patterns (DAMPs) and immune cell activation that exacerbate secondary damage and impair neurological recovery. …This DAMP-scavenging, IL-10-releas …

CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling.

Xu S, Wang J, Zhong J, Shao M, Jiang J, Song J, Zhu W, Zhang F, Xu H, Xu G, Zhang Y, Ma X, Lyu F.

Clin Transl Med. 2021 Jan;11(1):e269. doi: 10.1002/ctm2.269.

PMID: 33463071 Free PMC article.

BACKGROUND: Neuroinflammation-induced secondary injury is an important cause of sustained progression of spinal cord injury. …What’s more, we confirm the accumulation of HIF-1alpha promotes the overexpression of CD73 after spinal cord …

Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation.

Chu XL, Song XZ, Li Q, Li YR, He F, Gu XS, Ming D.

Neural Regen Res. 2022 Oct;17(10):2185-2193. doi: 10.4103/1673-5374.335823.

PMID: 35259827 Free PMC article. Review.

We summarize and discuss the basic mechanisms of PNI and of treatment via electrical stimulation. After PNI, activity in the central nervous system (spinal cord) is altered, which can limit regeneration of the damaged nerve. For example, cell apoptosis …

Astrocytic YAP Promotes the Formation of Glia Scars and Neural Regeneration after Spinal Cord Injury.

Xie C, Shen X, Xu X, Liu H, Li F, Lu S, Gao Z, Zhang J, Wu Q, Yang D, Bao X, Zhang F, Wu S, Lv Z, Zhu M, Xu D, Wang P, Cao L, Wang W, Yuan Z, Wang Y, Li Z, Teng H, Huang Z.

J Neurosci. 2020 Mar 25;40(13):2644-2662. doi: 10.1523/JNEUROSCI.2229-19.2020. Epub 2020 Feb 17.

PMID: 32066583 Free PMC article.

However, it is not clear whether YAP signaling participates in the process of the formation of glia scars after spinal cord injury (SCI). In this study, we found that YAP was upregulated and activated in astrocytes of C57BL/6 male mice after SCI in a Hippo pa …

Inflammatory Response to Spinal Cord Injury and Its Treatment.

Liu X, Zhang Y, Wang Y, Qian T.

World Neurosurg. 2021 Nov;155:19-31. doi: 10.1016/j.wneu.2021.07.148. Epub 2021 Aug 8.

PMID: 34375779 Free article. Review.

Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, affects thousands of human beings, and the pathologic changes after injury have been a hot spot for exploration in clinical medicine. …Primary injury occurs imm …

Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis.

Yao X, Zhang Y, Hao J, Duan HQ, Zhao CX, Sun C, Li B, Fan BY, Wang X, Li WX, Fu XH, Hu Y, Liu C, Kong XH, Feng SQ.

Neural Regen Res. 2019 Mar;14(3):532-541. doi: 10.4103/1673-5374.245480.

PMID: 30539824 Free PMC article.

Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. .. …

Treatment of spinal cord injury with mesenchymal stem cells.

Liau LL, Looi QH, Chia WC, Subramaniam T, Ng MH, Law JX.

Cell Biosci. 2020 Sep 22;10:112. doi: 10.1186/s13578-020-00475-3. eCollection 2020.

PMID: 32983406 Free PMC article. Review.

BACKGROUND: Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. …Application of MSCs may minimize secondary injury to the spinal …

An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury.

Gao X, Han Z, Huang C, Lei H, Li G, Chen L, Feng D, Zhou Z, Shi Q, Cheng L, Zhou X.

Bioact Mater. 2022 Jun 2;18:569-582. doi: 10.1016/j.bioactmat.2022.05.026. eCollection 2022 Dec.

PMID: 35845318 Free PMC article.

Spinal cord regeneration after a spinal cord injury (SCI) remains a difficult challenge due to the complicated inflammatory microenvironment and neuronal damage at the injury sites. …This study highlighted that the BSA-based biom …

Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation.

Zheng Y, Mao YR, Yuan TF, Xu DS, Cheng LM.

Neural Regen Res. 2020 Aug;15(8):1437-1450. doi: 10.4103/1673-5374.274332.

PMID: 31997803 Free PMC article. Review.

Spinal cord injury is linked to the interruption of neural pathways, which results in irreversible neural dysfunction. …This review evaluated the efficacy of neural stem cells and magnetic or electrical stimulation combined with rehabil …

Highly bioactive iridium metal-complex alleviates spinal cord injury via ROS scavenging and inflammation reduction.

Ji ZS, Gao GB, Ma YM, Luo JX, Zhang GW, Yang H, Li N, He QY, Lin HS.

Biomaterials. 2022 May;284:121481. doi: 10.1016/j.biomaterials.2022.121481. Epub 2022 Apr 1.

PMID: 35405576

Generation of a promising antioxidative reagent with superior biocompatibility is urgently needed to remedy spinal cord injuries (SCI), repair the damaged neurons and restrain the secondary injuries caused by inflammation-induced oxidative stress. Inhibitory element …

Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery.

Xi K, Gu Y, Tang J, Chen H, Xu Y, Wu L, Cai F, Deng L, Yang H, Shi Q, Cui W, Chen L.

Nat Commun. 2020 Sep 9;11(1):4504. doi: 10.1038/s41467-020-18265-3.

PMID: 32908131 Free PMC article.

The strategies concerning modification of the complex immune pathological inflammatory environment during acute spinal cord injury remain oversimplified and superficial. Inspired by the acidic microenvironment at acute injury sites, a functional pH-res …

An injectable and self-healing hydrogel with controlled release of curcumin to repair spinal cord injury.

Luo J, Shi X, Li L, Tan Z, Feng F, Li J, Pang M, Wang X, He L.

Bioact Mater. 2021 May 28;6(12):4816-4829. doi: 10.1016/j.bioactmat.2021.05.022. eCollection 2021 Dec.

PMID: 34136725 Free PMC article.

The harsh local micro-environment following spinal cord injury (SCI) remains a great challenge for neural regeneration. …The FC/FI-Cur hydrogel well reassembled extracellular matrix at the lesion site of rat spinal cord and exert …

Sodium selenite promotes neurological function recovery after spinal cord injury by inhibiting ferroptosis.

Chen YX, Zuliyaer T, Liu B, Guo S, Yang DG, Gao F, Yu Y, Yang ML, Du LJ, Li JJ.

Neural Regen Res. 2022 Dec;17(12):2702-2709. doi: 10.4103/1673-5374.339491.

PMID: 35662217 Free PMC article.

However, whether selenium can promote neurological function recovery after spinal cord injury as well as the underlying mechanism remain poorly understood. In this study, we injected sodium selenite (3 L, 2.5 M) into the injury site of a rat model of T …

Therapeutic induction of energy metabolism reduces neural tissue damage and increases microglia activation in severe spinal cord injury.

Dolci S, Mannino L, Bottani E, Campanelli A, Di Chio M, Zorzin S, D’Arrigo G, Amenta A, Segala A, Paglia G, Denti V, Fumagalli G, Nisoli E, Valerio A, Verderio C, Martano G, Bifari F, Decimo I.

Pharmacol Res. 2022 Apr;178:106149. doi: 10.1016/j.phrs.2022.106149. Epub 2022 Feb 28.

PMID: 35240272

Neural tissue has high metabolic requirements. Following spinal cord injury (SCI), the damaged tissue suffers from a severe metabolic impairment, which aggravates axonal degeneration and neuronal loss. …Metabolomic, immunohistological, and biochemica …

Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury.

Wu YQ, Xiong J, He ZL, Yuan Y, Wang BN, Xu JY, Wu M, Zhang SS, Cai SF, Zhao JX, Xu K, Zhang HY, Xiao J.

Acta Pharmacol Sin. 2022 Jun;43(6):1360-1371. doi: 10.1038/s41401-021-00759-5. Epub 2021 Sep 3.

PMID: 34480113

Spinal cord injury (SCI) is one kind of severe trauma for central nervous system. Myelin debris clearance and axon regeneration are essential for nerve regeneration after SCI. Metformin, a glucose-lowering drug, has been demonstrated to p …

Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.

Li Y, Yang L, Hu F, Xu J, Ye J, Liu S, Wang L, Zhuo M, Ran B, Zhang H, Ye J, Xiao J.

ACS Appl Mater Interfaces. 2022 Jun 8;14(22):25155-25172. doi: 10.1021/acsami.2c04341. Epub 2022 May 26.

PMID: 35618676

The repair of spinal cord injury (SCI) is still a tough clinical challenge and needs innovative therapies. Mitochondrial function is significantly compromised after SCI and has emerged as an important factor causing neuronal apoptosis and hindering functional …

CXCL12 promotes spinal nerve regeneration and functional recovery after spinal cord injury.

Li J, Wu Y, Chen P, Huang X, Liu Y, Peng M, Wu RQ.

Neuroreport. 2021 Apr 7;32(6):450-457. doi: 10.1097/WNR.0000000000001613.

PMID: 33657074

Spinal cord injury (SCI) leads to permanent loss of motor and sensory function due to the complex mechanisms of the external microenvironment and internal neurobiochemistry that restrict neuronal plasticity and axonal regeneration. …Taken together, t …

A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair.

Yang B, Liang C, Chen D, Cheng F, Zhang Y, Wang S, Shu J, Huang X, Wang J, Xia K, Ying L, Shi K, Wang C, Wang X, Li F, Zhao Q, Chen Q.

Bioact Mater. 2021 Dec 23;15:103-119. doi: 10.1016/j.bioactmat.2021.11.032. eCollection 2022 Sep.

PMID: 35386356 Free PMC article.

The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the biological microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells (NSCs) to repair SCI. …Overall, t …

Immunomodulatory Layered Double Hydroxide Nanoparticles Enable Neurogenesis by Targeting Transforming Growth Factor-β Receptor 2.

Zhu R, Zhu X, Zhu Y, Wang Z, He X, Wu Z, Xue L, Fan W, Huang R, Xu Z, Qi X, Xu W, Yu Y, Ren Y, Li C, Cheng Q, Ling L, Wang S, Cheng L.

ACS Nano. 2021 Feb 23;15(2):2812-2830. doi: 10.1021/acsnano.0c08727. Epub 2021 Feb 2.

PMID: 33527830

Immune microenvironment amelioration and reconstruction by functional biomaterials has become a promising strategy for spinal cord injury (SCI) recovery. In this study, we evaluated the neural regeneration and immunoregulation functions of Mg/Al …