Below are the top 20 results from the following PubMed search, sorted by “Best Match,” limited to the past 10 years: “alzheimer’s” AND (“neural regeneration” OR “neuron regeneration” OR “nerve regeneration”[Title/Abstract:~0])

(Last updated Spring 2023)

Knowledge domain and emerging trends in Alzheimer‘s disease: a scientometric review based on CiteSpace analysis.

Liu S, Sun YP, Gao XL, Sui Y.

Neural Regen Res. 2019 Sep;14(9):1643-1650. doi: 10.4103/1673-5374.255995.

PMID: 31089065 Free PMC article.

Alzheimer‘s disease is the most common cause of dementia. It is an increasingly serious global health problem and has a significant impact on individuals and society. However, the precise cause of Alzheimer‘s disease is still unknown. In this study, 11 …

Neural regeneration therapies for Alzheimer‘s and Parkinson’s disease-related disorders.

Reddy AP, Ravichandran J, Carkaci-Salli N.

Biochim Biophys Acta Mol Basis Dis. 2020 Apr 1;1866(4):165506. doi: 10.1016/j.bbadis.2019.06.020. Epub 2019 Jul 2.

PMID: 31276770 Free article. Review.

Neurodegenerative diseases are devastating mental illnesses without a cure. Alzheimer‘s disease (AD) characterized by memory loss, multiple cognitive impairments, and changes in personality and behavior. …

Stem Cell Therapy for Alzheimer‘s Disease.

Han F, Bi J, Qiao L, Arancio O.

Adv Exp Med Biol. 2020;1266:39-55. doi: 10.1007/978-981-15-4370-8_4.

PMID: 33105494

Alzheimer‘s disease (AD) is the most common neurodegenerative disease caused by eventually aggregated amyloid beta (Abeta) plaques in degenerating neurons of the aging brain. …Even though some cholinesterase inhibitors, NMDA receptor antagonist, and monoclonal ant …

Treatment of Alzheimer‘s disease with framework nucleic acids.

Shao X, Cui W, Xie X, Ma W, Zhan Y, Lin Y.

Cell Prolif. 2020 Apr;53(4):e12787. doi: 10.1111/cpr.12787. Epub 2020 Mar 12.

PMID: 32162733 Free PMC article.

OBJECTIVES: To provide a new research direction for nerve regeneration and strategy for Alzheimer‘s disease treatment, tetrahedral DNA nanostructures (TDNs)-novel tetrahedral framework nucleic acid molecule nanoparticles (tFNA) that can inhibit the apo …

Transthyretin: a multifaceted protein.

Vieira M, Saraiva MJ.

Biomol Concepts. 2014 Mar;5(1):45-54. doi: 10.1515/bmc-2013-0038.

PMID: 25372741 Free article. Review.

The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. Behavior, cognition, neuropeptide amidation, neurogenesis, nerve regeneration, axonal growth and 14-3-3zeta metabolism are some of the processes where TT …

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and Limitations.

Kolagar TA, Farzaneh M, Nikkar N, Khoshnam SE.

Curr Stem Cell Res Ther. 2020;15(2):102-110. doi: 10.2174/1574888X14666190823142911.

PMID: 31441732 Review.

There is urgent need to investigate therapeutic strategies and novel treatments for neural regeneration in disorders like Alzheimer‘s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Curre …

Ginsenoside Rd: A promising natural neuroprotective agent.

Chen YY, Liu QP, An P, Jia M, Luan X, Tang JY, Zhang H.

Phytomedicine. 2022 Jan;95:153883. doi: 10.1016/j.phymed.2021.153883. Epub 2021 Dec 8.

PMID: 34952508 Review.

Ginsenoside Rd is the active compound in P. ginseng known to have broad-spectrum pharmacological effects to reduce neurological damage that can lead to neurological diseases, including Alzheimer‘s disease, Parkinson’s disease, Huntington’s disease, dep …

Neurotrophic and Neuroregenerative Effects of GH/IGF1.

Bianchi VE, Locatelli V, Rizzi L.

Int J Mol Sci. 2017 Nov 17;18(11):2441. doi: 10.3390/ijms18112441.

PMID: 29149058 Free PMC article. Review.

This study aims to evaluate the effect of GH and IGF-1 on neurons, and their possible therapeutic clinical applications on neuron regeneration in human subjects. METHODS: In the literature, we searched the clinical trials and followed up studies in humans, which hav …

Study on the neuroprotective effects of Genistein on Alzheimer‘s disease.

Duan X, Li Y, Xu F, Ding H.

Brain Behav. 2021 May;11(5):e02100. doi: 10.1002/brb3.2100. Epub 2021 Mar 11.

PMID: 33704934 Free PMC article. Review.

Along with the aging of the world population, the incidence rate of Alzheimer‘s disease (AD) has been increasing. At present, AD has become one of the most serious problems faced by modern medicine. …

Sarsasapogenin attenuates Alzheimer-like encephalopathy in diabetes.

Zhang YM, Zheng T, Huang TT, Gu PP, Gou LS, Ma TF, Liu YW.

Phytomedicine. 2021 Oct;91:153686. doi: 10.1016/j.phymed.2021.153686. Epub 2021 Jul 23.

PMID: 34333330

BACKGROUND: A crosstalk exists between diabetes and Alzheimer‘s disease (AD), and diabetic encephalopathy displays AD-like disorders. …

Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer‘s disease.

Reza-Zaldivar EE, Hernández-Sapiéns MA, Gutiérrez-Mercado YK, Sandoval-Ávila S, Gomez-Pinedo U, Márquez-Aguirre AL, Vázquez-Méndez E, Padilla-Camberos E, Canales-Aguirre AA.

Neural Regen Res. 2019 Sep;14(9):1626-1634. doi: 10.4103/1673-5374.255978.

PMID: 31089063 Free PMC article.

Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment. The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mou …

Optogenetics and its application in neural degeneration and regeneration.

Ordaz JD, Wu W, Xu XM.

Neural Regen Res. 2017 Aug;12(8):1197-1209. doi: 10.4103/1673-5374.213532.

PMID: 28966628 Free PMC article. Review.

Neural degeneration and regeneration are important topics in neurological diseases. …It is aimed to provide a broader perspective on optogenetic therapeutic potential in neurodegeneration and neural regeneration….

Alzheimer‘s disease, neural stem cells and neurogenesis: cellular phase at single-cell level.

Cosacak MI, Bhattarai P, Kizil C.

Neural Regen Res. 2020 May;15(5):824-827. doi: 10.4103/1673-5374.268896.

PMID: 31719242 Free PMC article. Review.

Alzheimer‘s disease cannot be cured as of yet. Our current understanding on the causes of Alzheimer‘s disease is limited. …Therefore, understanding how neural stem cells can form new neurons in Alzheimer‘s disease brains holds an …

Advances in the roles and mechanisms of lignans against Alzheimer‘s disease.

Han N, Wen Y, Liu Z, Zhai J, Li S, Yin J.

Front Pharmacol. 2022 Oct 12;13:960112. doi: 10.3389/fphar.2022.960112. eCollection 2022.

PMID: 36313287 Free PMC article. Review.

Background: Alzheimer‘s disease (AD) is a serious neurodegenerative disease associated with the memory and cognitive impairment. …Methods: Relevant literature was extracted and retrieved from the databases including China National Knowledge Infrastructure (CNKI), …

A diselenide bond-containing ROS-responsive ruthenium nanoplatform delivers nerve growth factor for Alzheimer‘s disease management by repairing and promoting neuron regeneration.

Yuan X, Jia Z, Li J, Liu Y, Huang Y, Gong Y, Guo X, Chen X, Cen J, Liu J.

J Mater Chem B. 2021 Sep 29;9(37):7835-7847. doi: 10.1039/d1tb01290h.

PMID: 34586144

Alzheimer‘s disease (AD) is an incurable neurodegenerative disease. Repairing damaged nerves and promoting nerve regeneration are key ways to relieve AD symptoms. However, due to the lack of effective strategies to deliver nerve growth factor (N …

A Nanoformulation-Mediated Multifunctional Stem Cell Therapy with Improved Beta-Amyloid Clearance and Neural Regeneration for Alzheimer‘s Disease.

Huang D, Cao Y, Yang X, Liu Y, Zhang Y, Li C, Chen G, Wang Q.

Adv Mater. 2021 Apr;33(13):e2006357. doi: 10.1002/adma.202006357. Epub 2021 Feb 24.

PMID: 33624894

Alzheimer‘s disease (AD) is a common dementia that is currently incurable. …Here, the therapeutic potential of a nanoformulation-mediated neural stem cell (NSC) therapy capable of simultaneous Abeta clearance and neural regeneration is investi …

Modeling Neurodegenerative Disorders in Drosophila melanogaster.

Bolus H, Crocker K, Boekhoff-Falk G, Chtarbanova S.

Int J Mol Sci. 2020 Apr 26;21(9):3055. doi: 10.3390/ijms21093055.

PMID: 32357532 Free PMC article. Review.

In this review, we discuss recent progress in Drosophila modeling Alzheimer‘s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington’s Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or …

Effects of medicinal plants on Alzheimer‘s disease and memory deficits.

Akram M, Nawaz A.

Neural Regen Res. 2017 Apr;12(4):660-670. doi: 10.4103/1673-5374.205108.

PMID: 28553349 Free PMC article. Review.

Alzheimer‘s disease is an age-related neurodegenerative disorder characterized by memory deficits. …There is no cure for Alzheimer‘s disease, but symptomatic treatment may improve the memory and other dementia related problems. …

Aptamer and its applications in neurodegenerative diseases.

Qu J, Yu S, Zheng Y, Zheng Y, Yang H, Zhang J.

Cell Mol Life Sci. 2017 Feb;74(4):683-695. doi: 10.1007/s00018-016-2345-4. Epub 2016 Aug 25.

PMID: 27563707 Review.

This review presents recent advances in the aptamer generation and its merits and limitations, with emphasis on its applications in neurodegenerative diseases including Alzheimer‘s disease, Parkinson’s disease, transmissible spongiform encephalopathy, Hunting …

Propagation of Tau via Extracellular Vesicles.

Pérez M, Avila J, Hernández F.

Front Neurosci. 2019 Jul 2;13:698. doi: 10.3389/fnins.2019.00698. eCollection 2019.

PMID: 31312118 Free PMC article. Review.

Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, including synaptic transmission and nerve regeneration. However, exosomes in particular can also contribute to the development of neurodegenerative conditions such as Al …