Below are the top 20 results from the following PubMed search, sorted by “Best Match,” limited to the past 10 years: “multiple sclerosis” AND (“neural regeneration” OR “neuron regeneration” OR “nerve regeneration”[Title/Abstract:~0])

(Last updated Spring 2023)

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and Limitations.

Kolagar TA, Farzaneh M, Nikkar N, Khoshnam SE.

Curr Stem Cell Res Ther. 2020;15(2):102-110. doi: 10.2174/1574888X14666190823142911.

PMID: 31441732 Review.

There is urgent need to investigate therapeutic strategies and novel treatments for neural regeneration in disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Curre …

Optogenetics and its application in neural degeneration and regeneration.

Ordaz JD, Wu W, Xu XM.

Neural Regen Res. 2017 Aug;12(8):1197-1209. doi: 10.4103/1673-5374.213532.

PMID: 28966628 Free PMC article. Review.

Neural degeneration and regeneration are important topics in neurological diseases. …It is aimed to provide a broader perspective on optogenetic therapeutic potential in neurodegeneration and neural regeneration….

Neurotrophic factors and their effects in the treatment of multiple sclerosis.

Razavi S, Nazem G, Mardani M, Esfandiari E, Salehi H, Esfahani SH.

Adv Biomed Res. 2015 Feb 17;4:53. doi: 10.4103/2277-9175.151570. eCollection 2015.

PMID: 25802822 Free PMC article. Review.

These factors have an important role in neural regeneration, remyelination, and regulating the development of the peripheral and central nervous systems (PNS and CNS, respectively) by intracellular signaling through specific receptors. …The use of neurotrophic fac …

Autophagy and neurodegenerative disorders.

Kesidou E, Lagoudaki R, Touloumi O, Poulatsidou KN, Simeonidou C.

Neural Regen Res. 2013 Aug 25;8(24):2275-83. doi: 10.3969/j.issn.1673-5374.2013.24.007.

PMID: 25206537 Free PMC article. Review.

Aptamer and its applications in neurodegenerative diseases.

Qu J, Yu S, Zheng Y, Zheng Y, Yang H, Zhang J.

Cell Mol Life Sci. 2017 Feb;74(4):683-695. doi: 10.1007/s00018-016-2345-4. Epub 2016 Aug 25.

PMID: 27563707 Review.

This review presents recent advances in the aptamer generation and its merits and limitations, with emphasis on its applications in neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, transmissible spongiform encephalopathy, Huntington’s disease and …

Corneal Confocal Microscopy to Image Small Nerve Fiber Degeneration: Ophthalmology Meets Neurology.

Petropoulos IN, Bitirgen G, Ferdousi M, Kalteniece A, Azmi S, D’Onofrio L, Lim SH, Ponirakis G, Khan A, Gad H, Mohammed I, Mohammadi YE, Malik A, Gosal D, Kobylecki C, Silverdale M, Soran H, Alam U, Malik RA.

Front Pain Res (Lausanne). 2021 Aug 19;2:725363. doi: 10.3389/fpain.2021.725363. eCollection 2021.

PMID: 35295436 Free PMC article. Review.

Moreover, in clinical intervention trials of patients with diabetic and sarcoid neuropathy, corneal nerve regeneration occurs early and precedes an improvement in symptoms and neurophysiology. Corneal nerve fiber loss also occurs and is associated with diseas …

Periodontal ligament stem cells as a promising therapeutic target for neural damage.

Mohebichamkhorami F, Fattahi R, Niknam Z, Aliashrafi M, Khakpour Naeimi S, Gilanchi S, Zali H.

Stem Cell Res Ther. 2022 Jun 21;13(1):273. doi: 10.1186/s13287-022-02942-9.

PMID: 35729595 Free PMC article. Review.

PDLSCs can be a new clinical research target for Alzheimer’s disease treatment, multiple sclerosis and cerebral ischemia. Moreover, PDLSCs have beneficial effects on retinal ganglion cell regeneration and photoreceptor survival. PDLSCs can be a great source f …

RXRα Blocks Nerve Regeneration after Spinal Cord Injury by Targeting p66shc.

Yu P, Yang K, Jiang M.

Oxid Med Cell Longev. 2021 Feb 10;2021:8253742. doi: 10.1155/2021/8253742. eCollection 2021.

PMID: 33628383 Free PMC article.

Nerve regeneration after spinal cord injury is regulated by many factors. …After RXRalpha agonist or antagonist administration, we found that RXRalpha agonists inhibited nerve regeneration after spinal cord injury, while RXRalpha antagonists promoted …

Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs.

Naqvi S, Panghal A, Flora SJS.

Front Neurosci. 2020 Jun 9;14:494. doi: 10.3389/fnins.2020.00494. eCollection 2020.

PMID: 32581676 Free PMC article. Review.

Blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BSCFB) guard the CNS from harmful substances and pose as the major challenges in delivering drugs into CNS for treatment of CNS complications such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s …

Galectins and Their Ligand Glycoconjugates in the Central Nervous System Under Physiological and Pathological Conditions.

Nio-Kobayashi J, Itabashi T.

Front Neuroanat. 2021 Oct 15;15:767330. doi: 10.3389/fnana.2021.767330. eCollection 2021.

PMID: 34720894 Free PMC article. Review.

This review summarizes the current knowledge of the cellular expression and role of galectins in the CNS, and discusses their functions in neurite outgrowth, myelination, and neural stem/progenitor cell niches, as well as in ischemic/hypoxic/traumatic injuries and neurodeg …

Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS.

El Seblani N, Welleford AS, Quintero JE, van Horne CG, Gerhardt GA.

J Neurosci Methods. 2020 Apr 1;335:108623. doi: 10.1016/j.jneumeth.2020.108623. Epub 2020 Feb 3.

PMID: 32027890 Review.

The recent and rapid advancement of our understanding of the gene expression and corresponding biochemical profiles of Schwann cells, within the distal segments of injured peripheral nerves, has helped elucidate the potential mechanisms underlying the unique ability for these cel …

Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases.

Zou Y, Zhang WF, Liu HY, Li X, Zhang X, Ma XF, Sun Y, Jiang SY, Ma QH, Xu DE.

Neural Regen Res. 2017 Sep;12(9):1551-1558. doi: 10.4103/1673-5374.215268.

PMID: 29090003 Free PMC article. Review.

The contactin-associated protein (Caspr) family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. …We also analyzed the relationship between the Caspr family and neurodegenerative diseases, multiple sclerosis …

Human IL12p80 Promotes Murine Oligodendrocyte Differentiation to Repair Nerve Injury.

Chung YF, Chen JH, Li CW, Hsu HY, Chen YP, Wang CC, Chiu IM.

Int J Mol Sci. 2022 Jun 23;23(13):7002. doi: 10.3390/ijms23137002.

PMID: 35806005 Free PMC article.

Understanding the roles of neurotrophic factors and their molecular mechanisms on neuro-regeneration will not only benefit patients with neural damage but could potentially treat neurodegenerative disorders, such as amyotrophic lateral sclerosis. …These res …

Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications.

Sikiric P, Seiwerth S, Rucman R, Kolenc D, Vuletic LB, Drmic D, Grgic T, Strbe S, Zukanovic G, Crvenkovic D, Madzarac G, Rukavina I, Sucic M, Baric M, Starcevic N, Krstonijevic Z, Bencic ML, Filipcic I, Rokotov DS, Vlainic J.

Curr Neuropharmacol. 2016;14(8):857-865. doi: 10.2174/1570159×13666160502153022.

PMID: 27138887 Free PMC article. Review.

We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple sclerosis trial, native and stable in human gastric juice. …Besides, BPC 157 has neuroprotective effects: prote …

Engineering Biomaterials to Influence Oligodendroglial Growth, Maturation, and Myelin Production.

Russell LN, Lampe KJ.

Cells Tissues Organs. 2016;202(1-2):85-101. doi: 10.1159/000446645. Epub 2016 Oct 5.

PMID: 27701172 Review.

Millions of people suffer from damage or disease to the nervous system that results in a loss of myelin, such as through a spinal cord injury or multiple sclerosis. Diminished myelin levels lead to further cell death in which unmyelinated neurons die. …Cell therap …

A1 Adenosine Receptor Activation Modulates Central Nervous System Development and Repair.

Kashfi S, Ghaedi K, Baharvand H, Nasr-Esfahani MH, Javan M.

Mol Neurobiol. 2017 Dec;54(10):8128-8139. doi: 10.1007/s12035-016-0292-6. Epub 2016 Nov 26.

PMID: 27889899 Review.

Next, we summarize some of the most well-known biological effects of A(1)AR in the central nervous system (CNS) during development and adulthood, in addition to its role in nervous system regeneration and repair….

Regional gray matter atrophy and neuropsychologcal problems in relapsing-remitting multiple sclerosis.

Lin A, Chen F, Liu F, Li Z, Liu Y, Lin S, Wang X, Zhu J.

Neural Regen Res. 2013 Jul 25;8(21):1958-65. doi: 10.3969/j.issn.1673-5374.2013.21.004.

PMID: 25206504 Free PMC article.

In multiple sclerosis, gray matter atrophy is extensive, and cognitive deficits and mood disorders are frequently encountered. …Moreover, there is no correlation between cognitive disorders and MRI results in clinically isolated syndromes or in cases of definite …

Correlation between white matter damage and gray matter lesions in multiple sclerosis patients.

Han XM, Tian HJ, Han Z, Zhang C, Liu Y, Gu JB, Bakshi R, Cao X.

Neural Regen Res. 2017 May;12(5):787-794. doi: 10.4103/1673-5374.206650.

PMID: 28616036 Free PMC article.

These findings suggest that white matter fiber bundles are extensively injured in multiple sclerosis patients. The main areas of gray matter atrophy in multiple sclerosis are the frontal lobe, parietal lobe, caudate nucleus, parahippocampal gyrus, and …

Immunomodulation by dimethyl fumarate treatment improves mouse sciatic nerve regeneration.

Bombeiro AL, Pereira BTN, Bonfanti AP, Oliveira ALR.

Brain Res Bull. 2020 Jul;160:24-32. doi: 10.1016/j.brainresbull.2020.04.005. Epub 2020 Apr 17.

PMID: 32305403

Macrophage activation is improved by T helper (Th) lymphocytes, whose role remains few explored upon traumatic nerve injuries. Dimethyl fumarate (DMF) is the first-line drug for the treatment of multiple sclerosis due to its neuroprotective, anti-inflammatory …

The Olig family affects central nervous system development and disease.

Tan B, Yu J, Yin Y, Jia G, Jiang W, Yu L.

Neural Regen Res. 2014 Feb 1;9(3):329-36. doi: 10.4103/1673-5374.128232.

PMID: 25206819 Free PMC article. Review.

Neural cell differentiation and maturation is a critical step during central nervous system development. The oligodendrocyte transcription family (Olig family) is known to be an important factor in regulating neural cell differentiation. Because of this, the Olig fa …