Neuron Regeneration
(Last updated August 2023)
Liu S, Sun YP, Gao XL, Sui Y.
Neural Regen Res. 2019 Sep;14(9):1643-1650. doi: 10.4103/1673-5374.255995.
PMID: 31089065 Free PMC article.
Immunity to the microbiota promotes sensory neuron regeneration.
Enamorado M, Kulalert W, Han SJ, Rao I, Delaleu J, Link VM, Yong D, Smelkinson M, Gil L, Nakajima S, Linehan JL, Bouladoux N, Wlaschin J, Kabat J, Kamenyeva O, Deng L, Gribonika I, Chesler AT, Chiu IM, Le Pichon CE, Belkaid Y.
Cell. 2023 Feb 2;186(3):607-620.e17. doi: 10.1016/j.cell.2022.12.037. Epub 2023 Jan 13.
PMID: 36640762
Here, we show that, upon injury, adaptive responses to the microbiota directly promote sensory neuron regeneration. At homeostasis, tissue-resident commensal-specific T cells colocalize with sensory nerve fibers within the dermis, express a transcriptional pr …
Wang S, Zhu C, Zhang B, Hu J, Xu J, Xue C, Bao S, Gu X, Ding F, Yang Y, Gu X, Gu Y.
Biomaterials. 2022 Jan;280:121251. doi: 10.1016/j.biomaterials.2021.121251. Epub 2021 Nov 13.
PMID: 34810037 Free article.
A favorable microenvironment plays an important role in nerve regeneration. Extracellular matrix (ECM) derived from cultured cells or natural tissues can facilitate nerve regeneration in the presence of various microenvironmental cues, including bioche …
An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury.
Gao X, Han Z, Huang C, Lei H, Li G, Chen L, Feng D, Zhou Z, Shi Q, Cheng L, Zhou X.
Bioact Mater. 2022 Jun 2;18:569-582. doi: 10.1016/j.bioactmat.2022.05.026. eCollection 2022 Dec.
PMID: 35845318 Free PMC article.
In vivo experiments revealed that RA@BSA@Cur NPs regulated the phenotypic polarization of macrophages, inhibited the release of inflammatory mediators, promoted functional neuron regeneration and motor function, and further inhibited scar tissue formation. This stud …
Neuropeptides Involved in Facial Nerve Regeneration.
Kim I, Kim Y, Kang D, Jung J, Kim S, Rim H, Kim S, Yeo SG.
Biomedicines. 2021 Oct 29;9(11):1575. doi: 10.3390/biomedicines9111575.
PMID: 34829804 Free PMC article. Review.
Neuropeptides and neurotransmitters act as intermediaries to transmit impulses from one neuron to another via a synapse. These neuropeptides are also related to nerve degeneration and regeneration during nerve damage. …Therefore, they may be markers …
Liu B, Kong Y, Shi W, Kuss M, Liao K, Hu G, Xiao P, Sankarasubramanian J, Guda C, Wang X, Lei Y, Duan B.
Bioact Mater. 2021 Dec 14;14:61-75. doi: 10.1016/j.bioactmat.2021.11.022. eCollection 2022 Aug.
PMID: 35310346 Free PMC article.
Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden. …Several upregulated miRNAs, like miRNA-132-3p and miRNA-199b-5p, were highly related to neuroprotection, anti-inflammati …
Nanobiomaterials for neural regeneration.
Chen N, Tian L, He L, Ramakrishna S.
Neural Regen Res. 2016 Sep;11(9):1372-1374. doi: 10.4103/1673-5374.191195.
PMID: 27857724 Free PMC article. Review.
Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aim …
Adrenomedullin: an important participant in neurological diseases.
Li FJ, Zheng SR, Wang DM.
Neural Regen Res. 2020 Jul;15(7):1199-1207. doi: 10.4103/1673-5374.272567.
PMID: 31960799 Free PMC article. Review.
This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain, brain injury and nerve regeneration, and their treatment. As a newly characterized pronociceptive mediator, adrenomedullin has been shown to act as an upst …
Nerve regeneration in transplanted organs and tracer imaging studies: A review.
Huang Y, He Z, Manyande A, Feng M, Xiang H.
Front Bioeng Biotechnol. 2022 Aug 16;10:966138. doi: 10.3389/fbioe.2022.966138. eCollection 2022.
PMID: 36051591 Free PMC article. Review.
The technique of organ transplantation is well established and after transplantation the patient might be faced with the problem of nerve regeneration of the transplanted organ. Transplanted organs are innervated by the sympathetic, parasympathetic, and visceral sen …
Dental Pulp Stem Cells in Neuroregeneration.
Mohan SP, Ramalingam M.
J Pharm Bioallied Sci. 2020 Aug;12(Suppl 1):S60-S66. doi: 10.4103/jpbs.JPBS_229_20. Epub 2020 Aug 28.
PMID: 33149432 Free PMC article. Review.
Current medical and surgical treatment has not improved the quality of life to desired limits. Neural regeneration through stem cells may be ideal choice in current scenario. …
Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury.
Li L, Li Y, Fan Z, Wang X, Li Z, Wen J, Deng J, Tan D, Pan M, Hu X, Zhang H, Lai M, Guo J.
Front Cell Neurosci. 2019 Mar 21;13:108. doi: 10.3389/fncel.2019.00108. eCollection 2019.
PMID: 30949031 Free PMC article.
The present study indicates that AA has an unexpected function in facilitating nerve regeneration. Using a mouse model of sciatic nerve crush injury, we found that AA can significantly accelerate axonal regrowth in the early stage [3 days post-injury (dpi)], …
Tissue engineering for the repair of peripheral nerve injury.
Zhang PX, Han N, Kou YH, Zhu QT, Liu XL, Quan DP, Chen JG, Jiang BG.
Neural Regen Res. 2019 Jan;14(1):51-58. doi: 10.4103/1673-5374.243701.
PMID: 30531070 Free PMC article. Review.
Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. …The three key points in establishing a tissue engineering material are the biological scaffold material, the seed cells and various growth factors. Understanding the type o …
Proteomics and systems biology in optic nerve regeneration.
Meehan SD, Abdelrahman L, Arcuri J, Park KK, Samarah M, Bhattacharya SK.
Adv Protein Chem Struct Biol. 2021;127:249-270. doi: 10.1016/bs.apcsb.2021.03.002. Epub 2021 Apr 22.
PMID: 34340769
We present an overview of current state of proteomic approaches as applied to optic nerve regeneration in the historical context of nerve regeneration particularly central nervous system neuronal regeneration. …We present an account of the cur …
Nerve implants with bioactive interfaces enhance neurite outgrowth and nerve regeneration in vivo.
Wang Z, Zhang Y, Wang L, Ito Y, Li G, Zhang P.
Colloids Surf B Biointerfaces. 2022 Oct;218:112731. doi: 10.1016/j.colsurfb.2022.112731. Epub 2022 Jul 27.
PMID: 35917689
Nerve implants functionalized with growth factors and stem cells are critical to promote neurite outgrowth, regulate neurodifferentiation, and facilitate nerve regeneration. …The enhanced functional and structural nerve regeneration of injured …
Roles of neural stem cells in the repair of peripheral nerve injury.
Wang C, Lu CF, Peng J, Hu CD, Wang Y.
Neural Regen Res. 2017 Dec;12(12):2106-2112. doi: 10.4103/1673-5374.221171.
PMID: 29323053 Free PMC article. Review.
Currently, researchers are using neural stem cell transplantation to promote regeneration after peripheral nerve injury, as neural stem cells play an important role in peripheral nerve injury repair. …It can be concluded that neural ste …
Materials for Neural Differentiation, Trans-Differentiation, and Modeling of Neurological Disease.
Gong L, Cao L, Shen Z, Shao L, Gao S, Zhang C, Lu J, Li W.
Adv Mater. 2018 Apr;30(17):e1705684. doi: 10.1002/adma.201705684. Epub 2018 Mar 24.
PMID: 29573284 Review.
Neuron regeneration from pluripotent stem cells (PSCs) differentiation or somatic cells trans-differentiation is a promising approach for cell replacement in neurodegenerative diseases and provides a powerful tool for investigating neural development, modelin …
Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration.
Zhang F, Zhang M, Liu S, Li C, Ding Z, Wan T, Zhang P.
Gels. 2022 Jan 6;8(1):41. doi: 10.3390/gels8010041.
PMID: 35049576 Free PMC article. Review.
Peripheral nerve injury (PNI) occurs frequently, and the prognosis is unsatisfactory. …This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration….
Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review.
Rosso MPO, Buchaim DV, Kawano N, Furlanette G, Pomini KT, Buchaim RL.
Bioengineering (Basel). 2018 Jun 9;5(2):44. doi: 10.3390/bioengineering5020044.
PMID: 29890728 Free PMC article. Review.
In the qualitative aspect, it was observed that PBMT was able to accelerate the process of nerve regeneration, presenting an increase in the number of myelinated fibers and a better lamellar organization of myelin sheath, besides improvement of electrophysiological …
Current landscape in motoneuron regeneration and reconstruction for motor cranial nerve injuries.
Xie Y, Schneider KJ, Ali SA, Hogikyan ND, Feldman EL, Brenner MJ.
Neural Regen Res. 2020 Sep;15(9):1639-1649. doi: 10.4103/1673-5374.276325.
PMID: 32209763 Free PMC article. Review.
Despite these advances, patients continue to suffer from functional limitations relating to inadequate cranial nerve regeneration, aberrant reinnervation, or incomplete recovery of neuromuscular function. …Insights from these studies will shed light on recent prog …
Role of macrophages in peripheral nerve injury and repair.
Liu P, Peng J, Han GH, Ding X, Wei S, Gao G, Huang K, Chang F, Wang Y.
Neural Regen Res. 2019 Aug;14(8):1335-1342. doi: 10.4103/1673-5374.253510.
PMID: 30964051 Free PMC article. Review.
In this review, we discuss the activation of macrophages and their roles in severe peripheral nerve injury. We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated ner …
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