Neuron Regeneration Weekly Digest: From Microglia to Medicine—Unlocking New Paths in Neurological Healing

by | May 3, 2025 | Uncategorized | 0 comments

In the evolving landscape of neuroregenerative science, researchers are uncovering powerful mechanisms that could reshape how we approach spinal cord injuries and neurodegenerative diseases. From fine-tuned molecular processes like Fascin-1 phosphorylation that help clear cellular debris and support spinal recovery, to regenerative strategies that leverage stem cells and cellular reprogramming to combat brain aging, the field is moving toward more holistic, precision-based care. Even centuries-old healing systems like Traditional Chinese Medicine are gaining renewed relevance through modern network pharmacology, revealing how herbal compounds may act on multiple biological targets to support cognitive resilience and neural repair.

Together, these insights signal a pivotal shift toward more integrative and restorative approaches in neuroscience.

1. Dynamic phosphorylation of Fascin-1 orchestrates microglial phagocytosis and neurological recovery after spinal cord injury

New research reveals that dynamic phosphorylation of Fascin-1 plays a key role in enhancing microglial clearance of myelin debris, protecting neurons, and promoting functional recovery after spinal cord injury. Targeting the Mas1/PKCγ pathway offers a promising new direction for spinal cord repair strategies.

2. Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases

Exploring how rejuvenation, regeneration, and replacement (“R3” strategies) are reshaping treatments for neurodegenerative diseases, with a focus on reversing cellular aging and restoring brain health through stem cell therapy and reprogramming technologies.

3. Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine

Network pharmacology is helping reveal how traditional Chinese medicine can target multiple pathways in neurodegenerative diseases, offering new possibilities for more effective, multi-faceted treatments.

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Latest episodes

Neuron Regeneration Weekly Digest: The Expanding Landscape of Neural Repair and Disease Modulation

Neuron Regeneration Weekly Digest: Implant‑Free Brain Stimulation, Spinal Cord Revitalization, and Protein‑Recycling Pathways

In this post, we dive into three recent studies that exemplify this momentum. You’ll read how wireless light‑activated particles reversed Parkinson‑like symptoms in mice without implants; how a glycerol‑based hydrogel revived mitochondrial health and motor ability after severe spinal cord injury; and how decoding VPS35’s role in cellular recycling is opening new therapeutic avenues for both neurodegeneration and cancer. Together, these discoveries sketch an exciting roadmap for therapies that are smarter, kinder to the body, and increasingly within reach.