Below are the top 20 results from the following PubMed search, sorted by “Best Match,” limited to the past 10 years: “parkinson’s” AND (“neural regeneration” OR “neuron regeneration” OR “nerve regeneration”[Title/Abstract:~0])

(Last updated Spring 2023)

Neural regeneration therapies for Alzheimer’s and Parkinson‘s disease-related disorders.

Reddy AP, Ravichandran J, Carkaci-Salli N.

Biochim Biophys Acta Mol Basis Dis. 2020 Apr 1;1866(4):165506. doi: 10.1016/j.bbadis.2019.06.020. Epub 2019 Jul 2.

PMID: 31276770 Free article. Review.

Neurodegenerative diseases are devastating mental illnesses without a cure. Alzheimer’s disease (AD) characterized by memory loss, multiple cognitive impairments, and changes in personality and behavior. …

What and How Can Physical Activity Prevention Function on Parkinson‘s Disease?

Fan B, Jabeen R, Bo B, Guo C, Han M, Zhang H, Cen J, Ji X, Wei J.

Oxid Med Cell Longev. 2020 Feb 13;2020:4293071. doi: 10.1155/2020/4293071. eCollection 2020.

PMID: 32215173 Free PMC article. Review.

AIM: This study was aimed at investigating the effects and molecular mechanisms of physical activity intervention on Parkinson‘s disease (PD) and providing theoretical guidance for the prevention and treatment of PD. …Protective factors include alcohol, tobacco, c …

Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function.

Xiong M, Tao Y, Gao Q, Feng B, Yan W, Zhou Y, Kotsonis TA, Yuan T, You Z, Wu Z, Xi J, Haberman A, Graham J, Block J, Zhou W, Chen Y, Zhang SC.

Cell Stem Cell. 2021 Jan 7;28(1):112-126.e6. doi: 10.1016/j.stem.2020.08.014. Epub 2020 Sep 22.

PMID: 32966778 Free PMC article.

Although cell transplantation can rescue motor defects in Parkinson‘s disease (PD) models, whether and how grafts functionally repair damaged neural circuitry in the adult brain is not known. …These results indicate similarity in cell-type-specific pre- and …

Mitophagy in Parkinson‘s Disease: From Pathogenesis to Treatment.

Liu J, Liu W, Li R, Yang H.

Cells. 2019 Jul 12;8(7):712. doi: 10.3390/cells8070712.

PMID: 31336937 Free PMC article. Review.

Parkinson‘s disease (PD) is the second most common neurodegenerative disease. …

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Balancing Apoptosis and Autophagy for Parkinson‘s Disease Therapy: Targeting BCL-2.

Liu J, Liu W, Yang H.

ACS Chem Neurosci. 2019 Feb 20;10(2):792-802. doi: 10.1021/acschemneuro.8b00356. Epub 2019 Feb 11.

PMID: 30400738 Review.

Conversely, their imbalance is associated with neurodegenerative diseases such as Parkinson‘s disease (PD), which is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. …

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and Limitations.

Kolagar TA, Farzaneh M, Nikkar N, Khoshnam SE.

Curr Stem Cell Res Ther. 2020;15(2):102-110. doi: 10.2174/1574888X14666190823142911.

PMID: 31441732 Review.

There is urgent need to investigate therapeutic strategies and novel treatments for neural regeneration in disorders like Alzheimer’s disease (AD), Parkinson‘s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Curre …

Ginsenoside Rd: A promising natural neuroprotective agent.

Chen YY, Liu QP, An P, Jia M, Luan X, Tang JY, Zhang H.

Phytomedicine. 2022 Jan;95:153883. doi: 10.1016/j.phymed.2021.153883. Epub 2021 Dec 8.

PMID: 34952508 Review.

Ginsenoside Rd is the active compound in P. ginseng known to have broad-spectrum pharmacological effects to reduce neurological damage that can lead to neurological diseases, including Alzheimer’s disease, Parkinson‘s disease, Huntington’s disease, dep …

Curcumin can improve Parkinson‘s disease via activating BDNF/PI3k/Akt signaling pathways.

Jin T, Zhang Y, Botchway BOA, Zhang J, Fan R, Zhang Y, Liu X.

Food Chem Toxicol. 2022 Jun;164:113091. doi: 10.1016/j.fct.2022.113091. Epub 2022 May 6.

PMID: 35526734 Review.

Parkinson‘s disease is a common progressive neurodegenerative disease, and presently has no curative agent. …Here, we summarized the relationship between BDNF and PI3k/Akt signaling pathway, the main biological functions and neuroprotective effects of curcumin via …

Neurotrophic and Neuroregenerative Effects of GH/IGF1.

Bianchi VE, Locatelli V, Rizzi L.

Int J Mol Sci. 2017 Nov 17;18(11):2441. doi: 10.3390/ijms18112441.

PMID: 29149058 Free PMC article. Review.

This study aims to evaluate the effect of GH and IGF-1 on neurons, and their possible therapeutic clinical applications on neuron regeneration in human subjects. METHODS: In the literature, we searched the clinical trials and followed up studies in humans, which hav …

Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson‘s disease.

Zhang YN, Fan JK, Gu L, Yang HM, Zhan SQ, Zhang H.

J Neuroinflammation. 2021 Jan 18;18(1):23. doi: 10.1186/s12974-021-02079-1.

PMID: 33461598 Free PMC article.

BACKGROUND: Microglia activation induced by alpha-synuclein (alpha-syn) is one of the most important factors in Parkinson‘s disease (PD) pathogenesis. However, the molecular mechanisms by which alpha-syn exerts neuroinflammation and neurotoxicity remain largely elus …

Association of visual impairment with risk for future Parkinson‘s disease.

Zhu Z, Hu W, Liao H, Tan Z, Chen Y, Shi D, Shang X, Zhang X, Huang Y, Yu H, Wang W, He M, Yang X.

EClinicalMedicine. 2021 Nov 6;42:101189. doi: 10.1016/j.eclinm.2021.101189. eCollection 2021 Dec.

PMID: 34805812 Free PMC article.

BACKGROUND: Although visual dysfunction is one of the most common non-motor symptoms among patients with Parkinson‘s disease (PD), it is not known whether visual impairment (VI) predates the onset of clinical PD. …

Retinal age gap as a predictive biomarker of future risk of Parkinson‘s disease.

Hu W, Wang W, Wang Y, Chen Y, Shang X, Liao H, Huang Y, Bulloch G, Zhang S, Kiburg K, Zhang X, Tang S, Yu H, Yang X, He M, Zhu Z.

Age Ageing. 2022 Mar 1;51(3):afac062. doi: 10.1093/ageing/afac062.

PMID: 35352798 Free PMC article.

We aim to investigate the association between retinal age gap (retinal age-chronological age) and incident Parkinson‘s disease (PD). METHODS: a deep learning (DL) model trained on 19,200 fundus images of 11,052 chronic disease-free participants was used to predict r …

Optogenetics and its application in neural degeneration and regeneration.

Ordaz JD, Wu W, Xu XM.

Neural Regen Res. 2017 Aug;12(8):1197-1209. doi: 10.4103/1673-5374.213532.

PMID: 28966628 Free PMC article. Review.

Neural degeneration and regeneration are important topics in neurological diseases. …It is aimed to provide a broader perspective on optogenetic therapeutic potential in neurodegeneration and neural regeneration….

Oxidative Modification and Its Implications for the Neurodegeneration of Parkinson‘s Disease.

Zhao J, Yu S, Zheng Y, Yang H, Zhang J.

Mol Neurobiol. 2017 Mar;54(2):1404-1418. doi: 10.1007/s12035-016-9743-3. Epub 2016 Feb 3.

PMID: 26843115 Review.

Parkinson‘s disease (PD) is the second most common neurodegenerative disease. …

Modeling Neurodegenerative Disorders in Drosophila melanogaster.

Bolus H, Crocker K, Boekhoff-Falk G, Chtarbanova S.

Int J Mol Sci. 2020 Apr 26;21(9):3055. doi: 10.3390/ijms21093055.

PMID: 32357532 Free PMC article. Review.

In this review, we discuss recent progress in Drosophila modeling Alzheimer’s Disease, Parkinson‘s Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington’s Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or …

Aptamer and its applications in neurodegenerative diseases.

Qu J, Yu S, Zheng Y, Zheng Y, Yang H, Zhang J.

Cell Mol Life Sci. 2017 Feb;74(4):683-695. doi: 10.1007/s00018-016-2345-4. Epub 2016 Aug 25.

PMID: 27563707 Review.

This review presents recent advances in the aptamer generation and its merits and limitations, with emphasis on its applications in neurodegenerative diseases including Alzheimer’s disease, Parkinson‘s disease, transmissible spongiform encephalopathy, Hunting …

Graphene-Based Nanomaterials Toxicity in Fish.

Dasmahapatra AK, Dasari TPS, Tchounwou PB.

Rev Environ Contam Toxicol. 2019;247:1-58. doi: 10.1007/398_2018_15.

PMID: 30413975 Free PMC article. Review.

Due to their unique physicochemical properties, graphene-based nanoparticles (GPNs) constitute one of the most promising types of nanomaterials used in biomedical research. GPNs have been used as polymeric conduits for nerve regeneration and carriers for targeted dr …

Autophagy and neurodegenerative disorders.

Kesidou E, Lagoudaki R, Touloumi O, Poulatsidou KN, Simeonidou C.

Neural Regen Res. 2013 Aug 25;8(24):2275-83. doi: 10.3969/j.issn.1673-5374.2013.24.007.

PMID: 25206537 Free PMC article. Review.

Biomarkers and the Role of α-Synuclein in Parkinson‘s Disease.

Du T, Wang L, Liu W, Zhu G, Chen Y, Zhang J.

Front Aging Neurosci. 2021 Mar 23;13:645996. doi: 10.3389/fnagi.2021.645996. eCollection 2021.

PMID: 33833675 Free PMC article.

Parkinson‘s disease (PD) is a progressive neurodegenerative disorder characterized by the presence of alpha-synuclein (alpha-Syn)-rich Lewy bodies (LBs) and the preferential loss of dopaminergic (DA) neurons in the substantia nigra (SN) pars compacta (SNpc). …

Propagation of Tau via Extracellular Vesicles.

Pérez M, Avila J, Hernández F.

Front Neurosci. 2019 Jul 2;13:698. doi: 10.3389/fnins.2019.00698. eCollection 2019.

PMID: 31312118 Free PMC article. Review.

Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, including synaptic transmission and nerve regeneration. However, exosomes in particular can also contribute to the development of neurodegenerative conditions such as Alzhe …