Below are the top 20 results from the following PubMed search, sorted by “Best Match,” limited to the past 10 years: “peripheral nerve injury” AND (“neural regeneration” OR “neuron regeneration” OR “nerve regeneration”[Title/Abstract:~0])

(Last updated Spring 2023)

Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise.

Gordon T, English AW.

Eur J Neurosci. 2016 Feb;43(3):336-50. doi: 10.1111/ejn.13005. Epub 2015 Aug 14.

PMID: 26121368 Free PMC article. Review.

Enhancing the regeneration of axons is often considered to be a therapeutic target for improving functional recovery after peripheral nerve injury. …ES promotes nerve regeneration after delayed nerve repair in humans and rats. .. …

Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury.

Chen P, Piao X, Bonaldo P.

Acta Neuropathol. 2015 Nov;130(5):605-18. doi: 10.1007/s00401-015-1482-4. Epub 2015 Sep 29.

PMID: 26419777 Review.

Macrophages are the most notable immune cells that play key roles in PNS injury and repair. Upon peripheral nerve injury, a large number of macrophages are accumulated at the injury sites, where they not only contribute to Wallerian degeneration …

Stem-cell-based therapies to enhance peripheral nerve regeneration.

Kubiak CA, Grochmal J, Kung TA, Cederna PS, Midha R, Kemp SWP.

Muscle Nerve. 2020 Apr;61(4):449-459. doi: 10.1002/mus.26760. Epub 2019 Dec 3.

PMID: 31725911 Free article. Review.

Peripheral nerve injury remains a major cause of morbidity in trauma patients. Despite advances in microsurgical techniques and improved understanding of nerve regeneration, obtaining satisfactory outcomes after peripheral nerve …

Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation.

Chu XL, Song XZ, Li Q, Li YR, He F, Gu XS, Ming D.

Neural Regen Res. 2022 Oct;17(10):2185-2193. doi: 10.4103/1673-5374.335823.

PMID: 35259827 Free PMC article. Review.

Previous studies on the mechanisms of peripheral nerve injury (PNI) have mainly focused on the pathophysiological changes within a single injury site. …After PNI, the proximal end of the injured site sends out axial buds to innervate both the skin an …

Sensory nerve regeneration and reinnervation in muscle following peripheral nerve injury.

Adidharma W, Khouri AN, Lee JC, Vanderboll K, Kung TA, Cederna PS, Kemp SWP.

Muscle Nerve. 2022 Oct;66(4):384-396. doi: 10.1002/mus.27661. Epub 2022 Jul 2.

PMID: 35779064 Review.

Both play a major role in proprioception, sensorimotor extremity control feedback, and force regulation. After peripheral nerve injury, there is histological and electrophysiological evidence that sensory afferents can reinnervate muscle, including muscle tha …

Exosomes as a Promising Therapeutic Strategy for Peripheral Nerve Injury.

Yu T, Xu Y, Ahmad MA, Javed R, Hagiwara H, Tian X.

Curr Neuropharmacol. 2021;19(12):2141-2151. doi: 10.2174/1570159X19666210203161559.

PMID: 33535957 Free PMC article. Review.

Peripheral nerve injury has a high incidence and often leads to severe losses of sensory and motor functions in the afflicted limb. …However, they are still difficult to obtain satisfactory clinical results. Peripheral nerve regeneration …

Electrical Stimulation to Enhance Axon Regeneration After Peripheral Nerve Injuries in Animal Models and Humans.

Gordon T.

Neurotherapeutics. 2016 Apr;13(2):295-310. doi: 10.1007/s13311-015-0415-1.

PMID: 26754579 Free PMC article. Review.

Finally, the technique of inserting autologous nerve grafts that bridge between a donor nerve and an adjacent recipient denervated nerve stump significantly improves nerve regeneration after delayed nerve repair, the donor nerves sustaini …

Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration.

Qing L, Chen H, Tang J, Jia X.

Neurorehabil Neural Repair. 2018 Sep;32(9):765-776. doi: 10.1177/1545968318798955.

PMID: 30223738 Free PMC article. Review.

Peripheral nerve injury is a major clinical problem and often results in a poor functional recovery. …More specifically, microRNA carried by exosomes are involved in various key processes such as nerve and vascular regeneration, and exosomes o …

Augmenting Peripheral Nerve Regeneration with Adipose-Derived Stem Cells.

Jiang L, Mee T, Zhou X, Jia X.

Stem Cell Rev Rep. 2022 Feb;18(2):544-558. doi: 10.1007/s12015-021-10236-5. Epub 2021 Aug 20.

PMID: 34417730 Free PMC article. Review.

Peripheral nerve injuries (PNIs) are common and debilitating, cause significant health care costs for society, and rely predominately on autografts, which necessitate grafting a nerve section non-locally to repair the nerve injury. One possible …

Adipose tissue stem cells in peripheral nerve regeneration-In vitro and in vivo.

Rhode SC, Beier JP, Ruhl T.

J Neurosci Res. 2021 Feb;99(2):545-560. doi: 10.1002/jnr.24738. Epub 2020 Oct 18.

PMID: 33070351 Review.

After peripheral nerve injury, Schwann cells (SCs) are crucially involved in several steps of the subsequent regenerative processes, such as the Wallerian degeneration. …These cells share features with naturally occurring SCs, as they also promote nerve …

Heparin-Poloxamer Thermosensitive Hydrogel Loaded with bFGF and NGF Enhances Peripheral Nerve Regeneration in Diabetic Rats.

Li R, Li Y, Wu Y, Zhao Y, Chen H, Yuan Y, Xu K, Zhang H, Lu Y, Wang J, Li X, Jia X, Xiao J.

Biomaterials. 2018 Jun;168:24-37. doi: 10.1016/j.biomaterials.2018.03.044. Epub 2018 Mar 26.

PMID: 29609091 Free PMC article.

Peripheral nerve injury (PNI) is a major burden to society with limited therapeutic options, and novel biomaterials have great potential for shifting the current paradigm of treatment. With a rising prevalence of chronic illnesses such as diabetes mellitus (D …

Electrical stimulation to enhance peripheral nerve regeneration: Update in molecular investigations and clinical translation.

Zuo KJ, Gordon T, Chan KM, Borschel GH.

Exp Neurol. 2020 Oct;332:113397. doi: 10.1016/j.expneurol.2020.113397. Epub 2020 Jul 3.

PMID: 32628968 Review.

Peripheral nerve injuries are common and frequently result in incomplete functional recovery even with optimal surgical treatment. Permanent motor and sensory deficits are associated with significant patient morbidity and socioeconomic burden. Despite substantial re …

Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development.

Kong L, Gao X, Qian Y, Sun W, You Z, Fan C.

Theranostics. 2022 Jun 27;12(11):4993-5014. doi: 10.7150/thno.74571. eCollection 2022.

PMID: 35836812 Free PMC article. Review.

Peripheral nerve injury (PNI) caused by trauma, chronic disease and other factors may lead to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic pain. …For example, biomechanical factors-induced cluster gene expressio …

Magnesium-Encapsulated Injectable Hydrogel and 3D-Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration.

Yao Z, Yuan W, Xu J, Tong W, Mi J, Ho PC, Chow DHK, Li Y, Yao H, Li X, Xu S, Guo J, Zhu Q, Bian L, Qin L.

Adv Sci (Weinh). 2022 Jul;9(21):e2202102. doi: 10.1002/advs.202202102. Epub 2022 Jun 2.

PMID: 35652188 Free PMC article.

Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting. …In summary, the Mg(2+) -releasing hydrogel combined with the 3D-engineered PCL condui …

Mesenchymal Stem Cell Treatment Perspectives in Peripheral Nerve Regeneration: Systematic Review.

Lavorato A, Raimondo S, Boido M, Muratori L, Durante G, Cofano F, Vincitorio F, Petrone S, Titolo P, Tartara F, Vercelli A, Garbossa D.

Int J Mol Sci. 2021 Jan 8;22(2):572. doi: 10.3390/ijms22020572.

PMID: 33430035 Free PMC article.

The purpose of this systematic review is to discuss the features of different types of mesenchymal stem cells (MSCs) relevant for peripheral nerve regeneration after nerve injury. The published literature was reviewed following the Preferred Rep …

Conductive Nerve Guidance Conduits Based on Morpho Butterfly Wings for Peripheral Nerve Repair.

Hu Y, Chen Z, Wang H, Guo J, Cai J, Chen X, Wei H, Qi J, Wang Q, Liu H, Zhao Y, Chai R.

ACS Nano. 2022 Feb 22;16(2):1868-1879. doi: 10.1021/acsnano.1c11627. Epub 2022 Feb 3.

PMID: 35112853

Peripheral nerve injury (PNI), causing loss of sensory and motor function, is a complex and challenging disease in the clinic due to the restricted regeneration capacity. Nerve guidance conduits (NGCs) have become a promising substitute for p …

Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice.

Xu J, Wen J, Fu L, Liao L, Zou Y, Zhang J, Deng J, Zhang H, Liu J, Wang X, Zuo D, Guo J.

J Neuroinflammation. 2021 Oct 15;18(1):234. doi: 10.1186/s12974-021-02292-y.

PMID: 34654444 Free PMC article.

Recently, drugs targeting the RhoA pathway have been widely used to promote peripheral axonal regeneration. However, the role of RhoA in macrophage during Wallerian degeneration and nerve regeneration after peripheral nerve injury …

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Cortical plasticity and nerve regeneration after peripheral nerve injury.

Li C, Liu SY, Pi W, Zhang PX.

Neural Regen Res. 2021 Aug;16(8):1518-1523. doi: 10.4103/1673-5374.303008.

PMID: 33433465 Free PMC article.

With the development of neuroscience, substantial advances have been achieved in peripheral nerve regeneration over the past decades. However, peripheral nerve injury remains a critical public health problem because of the subsequent impa …

Effect of Exosomes from Rat Adipose-Derived Mesenchymal Stem Cells on Neurite Outgrowth and Sciatic Nerve Regeneration After Crush Injury.

Bucan V, Vaslaitis D, Peck CT, Strauß S, Vogt PM, Radtke C.

Mol Neurobiol. 2019 Mar;56(3):1812-1824. doi: 10.1007/s12035-018-1172-z. Epub 2018 Jun 21.

PMID: 29931510 Free PMC article.

Peripheral nerve injury requires optimal conditions in both macro-environment and microenvironment for promotion of axonal regeneration. However, most repair strategies of traumatic peripheral nerve injury often lead to dissatisfyi …

In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration.

Li A, Pereira C, Hill EE, Vukcevich O, Wang A.

Curr Neuropharmacol. 2022;20(2):344-361. doi: 10.2174/1570159X19666210407155543.

PMID: 33827409 Free PMC article. Review.

Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery from these injuries can be expectedly poor, especially in proximal injuries. In order to study and improve peripheral nerve regeneration, scientists rely …