Below are the top 20 results from the following PubMed search, sorted by “Best Match,” limited to the past 10 years: “Stroke” AND (“neural regeneration” OR “neuron regeneration” OR “nerve regeneration”)

(Last updated Spring 2023)

A Review of Exercise-Induced Neuroplasticity in Ischemic Stroke: Pathology and Mechanisms.

Xing Y, Bai Y.

Mol Neurobiol. 2020 Oct;57(10):4218-4231. doi: 10.1007/s12035-020-02021-1. Epub 2020 Jul 20.

PMID: 32691303 Review.

After ischemic stroke, survivors experience motor dysfunction and deterioration of memory and cognition. …In this review, our aim was to discuss the mechanisms by which exercise-induced neuroplasticity improves motor function and cognitive ability after ischemic strok …

Microglial phagocytosis and regulatory mechanisms after stroke.

Chen W, Zhang Y, Zhai X, Xie L, Guo Y, Chen C, Li Y, Wang F, Zhu Z, Zheng L, Wan J, Li P.

J Cereb Blood Flow Metab. 2022 Sep;42(9):1579-1596. doi: 10.1177/0271678X221098841. Epub 2022 May 1.

PMID: 35491825

Stroke, including ischemic stroke and hemorrhagic stroke can cause massive neuronal death and disruption of brain structure, which is followed by secondary inflammatory injury initiated by pro-inflammatory molecules and cellular debris. …An optimal immune r …

Regulatory T cells in ischemic stroke.

Wang H, Wang Z, Wu Q, Yuan Y, Cao W, Zhang X.

CNS Neurosci Ther. 2021 Jun;27(6):643-651. doi: 10.1111/cns.13611. Epub 2021 Jan 20.

PMID: 33470530 Free PMC article. Review.

They participate in the inflammatory response and neuroplasticity process of ischemic stroke by various mechanisms, such as secretion of anti-inflammatory factors, inhibition of pro-inflammatory factors, induction of cell lysis, production of the factors that promote ne …

A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke.

Huang Q, Zhong W, Hu Z, Tang X.

J Neuroinflammation. 2018 Dec 20;15(1):348. doi: 10.1186/s12974-018-1387-y.

PMID: 30572925 Free PMC article. Review.

Ischemic stroke starts a series of pathophysiological processes that cause brain injury. …In general, cav-1 reduces BBB permeability mainly by downregulating MMP9, reduces neuroinflammation through influencing cytokines and inflammatory cells, promotes nerve re …

Agonistic analog of growth hormone-releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke.

Liu Y, Yang J, Che X, Huang J, Zhang X, Fu X, Cai J, Yao Y, Zhang H, Cai R, Su X, Xu Q, Ren F, Cai R, Schally AV, Zhou MS.

Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2109600118. doi: 10.1073/pnas.2109600118.

PMID: 34782465 Free PMC article.

Ischemic stroke can induce neurogenesis. However, most stroke-generated newborn neurons cannot survive. …MR-409 also enhances the proliferation and inhibits apoptosis of neural stem cells treated with oxygen and glucose deprivation-reperfusion. …

M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice.

Li Y, Liu Z, Song Y, Pan JJ, Jiang Y, Shi X, Liu C, Ma Y, Luo L, Mamtilahun M, Shi Z, Khan H, Xie Q, Wang Y, Tang Y, Zhang Z, Yang GY.

Theranostics. 2022 Apr 24;12(7):3553-3573. doi: 10.7150/thno.68895. eCollection 2022.

PMID: 35547763 Free PMC article.

Rationale: White matter repair is critical for the cognitive and neurological functional recovery after ischemic stroke. M2 microglia are well-documented to enhance remyelination and their extracellular vesicles (EVs) mediate cellular function after brain injury. …Conclu …

p53 Inhibition Protects against Neuronal Ischemia/Reperfusion Injury by the p53/PRAS40/mTOR Pathway.

Zhao J, Dong Y, Chen X, Xiao X, Tan B, Chen G, Hu J, Qi D, Li X, Xie R.

Oxid Med Cell Longev. 2021 Dec 3;2021:4729465. doi: 10.1155/2021/4729465. eCollection 2021.

PMID: 34900085 Free PMC article.

Within this study, we aimed to explore whether p53 inhibition exerts protective effects via the p53/PRAS40/mTOR pathway after stroke and its potential mechanism. Both an in vitro oxygen-glucose deprivation (OGD) model with a primary neuronal culture and in vivo stroke …

Angiogenesis after ischemic stroke.

Fang J, Wang Z, Miao CY.

Acta Pharmacol Sin. 2023 Feb 24. doi: 10.1038/s41401-023-01061-2. Online ahead of print.

PMID: 36829053 Review.

Owing to its high disability and mortality rates, stroke has been the second leading cause of death worldwide. Since the pathological mechanisms of stroke are not fully understood, there are few clinical treatment strategies available with an exception of tissue pla …

Adrenomedullin: an important participant in neurological diseases.

Li FJ, Zheng SR, Wang DM.

Neural Regen Res. 2020 Jul;15(7):1199-1207. doi: 10.4103/1673-5374.272567.

PMID: 31960799 Free PMC article. Review.

This review summarizes the role of adrenomedullin in neuropathological disorders, including pathological pain, brain injury and nerve regeneration, and their treatment. As a newly characterized pronociceptive mediator, adrenomedullin has been shown to act as an upst …

Design and Fabrication of Polymeric Hydrogel Carrier for Nerve Repair.

Ma X, Wang M, Ran Y, Wu Y, Wang J, Gao F, Liu Z, Xi J, Ye L, Feng Z.

Polymers (Basel). 2022 Apr 11;14(8):1549. doi: 10.3390/polym14081549.

PMID: 35458307 Free PMC article. Review.

Nerve regeneration and repair still remain a huge challenge for both central nervous and peripheral nervous system. …Furthermore, the modulation of the physical and chemical properties of hydrogels is also discussed in detail in order to obtain a better therapeuti …

Neural regeneration by regionally induced stem cells within post-stroke brains: Novel therapy perspectives for stroke patients.

Nakagomi T, Takagi T, Beppu M, Yoshimura S, Matsuyama T.

World J Stem Cells. 2019 Aug 26;11(8):452-463. doi: 10.4252/wjsc.v11.i8.452.

PMID: 31523366 Free PMC article. Review.

Ischemic stroke is a critical disease which causes serious neurological functional loss such as paresis. …Thus, regional stem cells that are present and/or induced in the CNS may be ideal when considering a treatment following ischemic stroke. In this context, we …

Communications Between Peripheral and the Brain-Resident Immune System in Neuronal Regeneration After Stroke.

Liu F, Cheng X, Zhong S, Liu C, Jolkkonen J, Zhang X, Liang Y, Liu Z, Zhao C.

Front Immunol. 2020 Sep 18;11:1931. doi: 10.3389/fimmu.2020.01931. eCollection 2020.

PMID: 33042113 Free PMC article. Review.

Cerebral ischemia may cause irreversible neural network damage and result in functional deficits. Targeting neuronal repair after stroke potentiates the formation of new connections, which can be translated into a better functional outcome. Innate and adaptive immun …

Netrin-1 in Post-stroke Neuroprotection: Beyond Axon Guidance Cue.

Luo Y, Liao S, Yu J.

Curr Neuropharmacol. 2022;20(10):1879-1887. doi: 10.2174/1570159X20666220302150723.

PMID: 35236266 Free PMC article. Review.

BACKGROUND: Stroke, especially ischemic stroke, is a leading disease associated with death and long-term disability with limited therapeutic options. …Importantly, accumulating evidence has shown that netrin-1 can manifest its beneficial functions to brain tissue …

Interactions between remote ischemic conditioning and post-stroke sleep regulation.

Wang X, Ji X.

Front Med. 2021 Dec;15(6):867-876. doi: 10.1007/s11684-021-0887-9. Epub 2021 Nov 23.

PMID: 34811643 Review.

Sleep disturbances are common in patients with stroke, and sleep quality has a critical role in the onset and outcome of stroke. Poor sleep exacerbates neurological injury, impedes nerve regeneration, and elicits serious complications. Thus, exploring …

Association of Retinal Age Gap With Arterial Stiffness and Incident Cardiovascular Disease.

Zhu Z, Chen Y, Wang W, Wang Y, Hu W, Shang X, Liao H, Shi D, Huang Y, Ha J, Tan Z, Kiburg KV, Zhang X, Tang S, Yu H, Yang X, He M.

Stroke. 2022 Nov;53(11):3320-3328. doi: 10.1161/STROKEAHA.122.038809. Epub 2022 Jul 26.

PMID: 35880520 Free article.

Therapeutic strategy against ischemic stroke with the concept of neurovascular unit.

Ozaki T, Nakamura H, Kishima H.

Neurochem Int. 2019 Jun;126:246-251. doi: 10.1016/j.neuint.2019.03.022. Epub 2019 Apr 1.

PMID: 30946849 Review.

Stroke is one of the leading causes of death and disability globally. …Therefore, development of other treatment approaches such as developing neuroprotective drugs and nerve regeneration therapy is required to overcome ischemic stroke. …

Hyperbaric oxygen therapy in experimental and clinical stroke.

Zhai WW, Sun L, Yu ZQ, Chen G.

Med Gas Res. 2016 Jul 11;6(2):111-118. doi: 10.4103/2045-9912.184721. eCollection 2016 Apr-Jun.

PMID: 27867477 Free PMC article. Review.

Stroke, which is defined as a neurologic deficit caused by sudden impaired blood supply, has been considered as a common cause of death and disability for decades. …Hyperbaric oxygen therapy (HBOT) has been frequently applied and investigated in stroke since 1960s …

The Role of Nanomaterials in Stroke Treatment: Targeting Oxidative Stress.

Song G, Zhao M, Chen H, Lenahan C, Zhou X, Ou Y, He Y.

Oxid Med Cell Longev. 2021 Mar 17;2021:8857486. doi: 10.1155/2021/8857486. eCollection 2021.

PMID: 33815664 Free PMC article. Review.

In stroke, oxidative stress leads to further damage to the brain tissue. …This review summarizes the characteristics and progress of nanomaterials in the application of antioxidant therapy in stroke, including ischemic stroke, hemorrhagic stroke, and …

Adult Neurogenesis Following Ischemic Stroke and Implications for Cell-Based Therapeutic Approaches.

Xie F, Liu H, Liu Y.

World Neurosurg. 2020 Jun;138:474-480. doi: 10.1016/j.wneu.2020.02.010. Epub 2020 Mar 5.

PMID: 32147554 Review.

Ischemic stroke is one of the most intractable diseases of the central nervous system and is also a major cause of mortality and disability in adult humans. …At present, accumulating evidence suggests that adult neurogenesis is a novel topic with extensive research on it …

Neuroplasticity in post-stroke gait recovery and noninvasive brain stimulation.

Xu Y, Hou QH, Russell SD, Bennett BC, Sellers AJ, Lin Q, Huang DF.

Neural Regen Res. 2015 Dec;10(12):2072-80. doi: 10.4103/1673-5374.172329.

PMID: 26889202 Free PMC article. Review.

Gait disorders drastically affect the quality of life of stroke survivors, making post-stroke rehabilitation an important research focus. …While post-stroke neuroplasticity for gait recovery is characterized by use-dependent plasticity, it evolves over time …