In the evolving landscape of neuroregenerative science, researchers are uncovering powerful mechanisms that could reshape how we approach spinal cord injuries and neurodegenerative diseases. From fine-tuned molecular processes like Fascin-1 phosphorylation that help clear cellular debris and support spinal recovery, to regenerative strategies that leverage stem cells and cellular reprogramming to combat brain aging, the field is moving toward more holistic, precision-based care. Even centuries-old healing systems like Traditional Chinese Medicine are gaining renewed relevance through modern network pharmacology, revealing how herbal compounds may act on multiple biological targets to support cognitive resilience and neural repair.
Together, these insights signal a pivotal shift toward more integrative and restorative approaches in neuroscience.
1. Dynamic phosphorylation of Fascin-1 orchestrates microglial phagocytosis and neurological recovery after spinal cord injury
New research reveals that dynamic phosphorylation of Fascin-1 plays a key role in enhancing microglial clearance of myelin debris, protecting neurons, and promoting functional recovery after spinal cord injury. Targeting the Mas1/PKCγ pathway offers a promising new direction for spinal cord repair strategies.
2. Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases
Exploring how rejuvenation, regeneration, and replacement (“R3” strategies) are reshaping treatments for neurodegenerative diseases, with a focus on reversing cellular aging and restoring brain health through stem cell therapy and reprogramming technologies.
3. Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine
Network pharmacology is helping reveal how traditional Chinese medicine can target multiple pathways in neurodegenerative diseases, offering new possibilities for more effective, multi-faceted treatments.
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