From novel drug candidates to advanced neurostimulation techniques, scientists are uncovering promising new ways to repair and protect the nervous system. Recent studies explore how certain psychoactive compounds might target Alzheimer’s disease at the molecular level, evaluate the real-world effectiveness of a Parkinson’s therapy, and reveal how a combined brain-and-spinal stimulation approach can boost regeneration after spinal cord injury.
Together, these findings highlight the diverse and rapidly evolving strategies aimed at restoring function and slowing neurodegeneration.
1. Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer’s disease
Emerging research is exploring how psychoactive substances—from cannabinoids and psychedelics to CNS stimulants—may target key mechanisms behind Alzheimer’s disease. While clinical use is still under scrutiny, these compounds are showing potential in reducing inflammation, supporting cognitive function, and modulating neurodegeneration at the molecular level.
2. Use of safinamide for treatment of Parkinson disease: real-world data from Spain
Researchers are reevaluating psychoactive substances—including cannabinoids, stimulants, and psychedelics—for their potential to slow or modify Alzheimer’s disease progression. With effects on neuroinflammation, synaptic health, and memory, these compounds may offer novel therapeutic directions, though safety and efficacy remain under close investigation.
3. Transcranial iTBS Combined With Trans‐Spinal iTBS Targeting PDE1A/cAMP/PKA Axis Regulates Neural Regeneration After Spinal Cord Injury
Researchers found that combining transcranial and spinal intermittent theta burst stimulation (iTBS) significantly improved motor function and neural repair in spinal cord–injured rats. This dual-target approach appears to promote regeneration by modulating the PDE1A–cAMP–PKA signaling pathway, opening the door to more effective, non-invasive rehabilitation strategies.
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